Our Work
Our Key Contributions
March 2020
March 2020
Discovered the link between RaTG13 and BtCoV4991
In March 2020, Rossana Segreto made the first public connection between RaTG13 and BtCoV4991 and in April 2020 published a preprint about the possibility they might be the same virus.

April 2020
April 2020
First comprehensive analysis of gain-of-function work done at WIV
In April 2020, Yuri Deigin published the first in-depth analysis of gain-of-function work done at WIV and how it could have led to SARS2 leaking from their lab.

April 2020
April 2020
Discovered the link between RaTG13 and the Mojiang mine
In April 2020, Yuri Deigin traced the origin of RaTG13 to the mine in Mojiang, which then prompted TheSeeker to discover a Master’s thesis and a PhD thesis on an unusual case of pneumonia in the same mineshaft where RaTG13, the closest relative to SARS-CoV-2, was found. Mona and Rahul Bahulikar later published a paper on these Mojiang miners’ cases.
May 2020
May 2020
Discovered that the WIV virus database has been taken offline
In May 2020, Yuri Deigin was the first to publicly report the deletion of the WIV virus database.

May 2020
May 2020
The peculiarities of the FCS: CGG-CGG codons and FauI site
In May 2020, @ydeigin pointed out the peculiar CGG-CGG codons and FauI restriction enzyme site in the PRRA insertion in SARS2 which created a novel furin cleavage site.
June 2020
June 2020
Discovered that RaTG13 was sequenced long before 2020
In June 2020, after WIV released RaTG13 sequencing data, Francisco de Asis found that RaTG13 was sequenced long before the pandemic rather than after, as was implied in WIV’s February 2020 Nature paper. RaTG13 amplicon fasta headers showed dates back to 2017 and 2018, and also a label referred as “7896” pointing to one of the eight viruses close to SARS-CoV-2 after RaTG13.
November 2020
November 2020
Published the most widely cited lab leak hypothesis peer reviewed paper
In November 2020, Rossana Segreto and Yuri Deigin published their paper “The genetic structure of SARS-CoV-2 does not rule out a laboratory origin”. Their paper was mentioned by several mainstream media outlets, as one of the first peer reviewed papers considering a possible lab origin of SARS-CoV-2. It has since become the most widely cited lab leak hypothesis paper, as well as one with the highest Altmetric score.

May 2021
May 2021
Published 3 more WIV PhD theses showing work done on RaTG13/BtCoV4991
In May 2021, TheSeeker has published 3 more PhD theses from WIV which showed there was active work done on RaTG13/BtCoV4991, including full genome sequencing in the 2019 PhD thesis. We also pointed out that the BtCoV4991 spike gene seems to have a 1% difference from the RaTG13 spike gene, raising questions as to whether the two might actually not be identical.
Our Publications
Lab-Made? SARS-CoV-2 Genealogy Through the Lens of Gain-of-Function Research

Lethal Pneumonia Cases in Mojiang Miners (2012) and the Mineshaft Could Provide Important Clues to the Origin of SARS-CoV-2

By Monali C. Rahalkar and Rahul A. Bahulikar

The genetic structure of SARS-CoV-2 does not rule out a laboratory origin
By Rossana Segreto and Yuri Deigin

Should we discount the laboratory origin of COVID-19?
By Rossana Segreto, Yuri Deigin, Kevin McCairn, Alejandro Sousa, Dan Sirotkin, Karl Sirotkin, Jonathan J Couey, Adrian Jones, Daoyu Zhang

SARS-CoV-2's claimed natural origin is undermined by issues with genome sequences of its relative strains: Coronavirus sequences RaTG13, MP789 and RmYN02 raise multiple questions to be critically addressed by the scientific community
By Yuri Deigin and Rossana Segreto

The genetic structure of SARS-CoV-2 is consistent with both natural or laboratory origin: Response to Tyshkovskiy and Panchin
By Yuri Deigin and Rossana Segreto

An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2
By Jacques van Helden, Colin D Butler, Guillaume Achaz, Bruno Canard, Didier Casane, Jean-Michel Claverie, Fabien Colombo, Virginie Courtier, Richard H Ebright, François Graner, Milton Leitenberg, Serge Morand, Nikolai Petrovsky, Rossana Segreto, Etienne Decroly, José Halloy

Outlines of a probabilistic evaluation of possible SARS-CoV-2 origins
By Gilles Demaneuf, Rodolphe de Maistre

Unexpected novel Merbecovirus discoveries in agricultural sequencing datasets from Wuhan, China
By Daoyu Zhang, Adrian Jones, Yuri Deigin, Karl Sirotkin, Alejandro Sousa

Cloning vectors and contamination in metagenomic datasets raise concerns over pangolin CoV genome authenticity
By Adrian Jones, Daoyu Zhang, Yuri Deigin, Steven C. Quay

CONTAMINATION OR VACCINE RESEARCH? RNA Sequencing data of early COVID-19 patient samples show abnormal presence of vectorized H7N9 hemagglutinin segment
By Steven C. Quay, Monali C. Rahalkar, Adrian Jones , Rahul A. Bahulikar

The Anomalous Nature of the Fecal Swab Data, Receptor Binding Domain and Other Questions in RaTG13 Genome
By Monali C. Rahalkar and Rahul A. Bahulikar

An Introduction to Wuhan BSL-4 Engineering